AB0651 INDIRECT HEALTH RELATED COST IN pSS PATIENTS IN RELATION TO SYMPTOM BASED ENDOTYPES

Background Primary Sjögren’s Syndrome (pSS) is characterised by oral and ocular dryness, possible development of systemic manifestations, increased lymphoma risk, a highly diverse patient burden. To address this heterogeneity Tarn identified four endotypes based on patient-reported symptoms fatigue, pain, anxiety depression: low symptom burden (LSB), pain dominant with fatigue (PDF), dryness (DDF) high (HSB).(1) Objectives The aim study was to explore indirect health related costs in relation symptom-based cohort patients definite suspected pSS. Methods Data from the Belgian Transition Trial (BeSSTT) were used which positive for at least one 2016 ACR/EULAR classification criteria, enrolled. Patients considered ‘definite pSS’ when fulfilling these ‘suspected otherwise. Newcastle Stratification Tool (NSST), developed provided et al., applied stratify into endotypes. reported their current work status sick leave past year completed Work Productivity Activity Impairment questionnaire (WPAI). Results Application NSST tool resulted 4 endotypes, both (LSB n=23, DDF n=33, PDF n=82, HSB n=30) pSS n=14, n=22, n=48, n=21). majority female (158, 88.8%) mean±SD age 53.4±14.7, no significant differences between (p=0.365 p=0.415). Definite LSB significantly less invalidity (p=0.020). A numerically higher proportion working part time employment due (p=0.063). However, hours did not differ In contrast, more productivity loss during job than those (p<0.001), led total impairment (p<0.001). addition, endotype daily activities besides (69%, p<0.001). No concerning characteristics observed same endotype. Conclusion encounter other while working. report paid work, entails large as predominantly disease. Moreover, associated appears influence ability independent diagnosis. Reference [1]Tarn JR al, Lancet Rheumatol. 2019 Table 1. Job per Continuous data presented mean (SD), categorical number (%). without (n=10) (n=18) (n=44) (n=17) p Student/retired Unemployed Invalidity 10 (100.0) 0 9 (50.0) 5 (27.8) (22.2) 17 (38.6) 6 (13.6) 21 (47.7) (35.3) (29.4) 0.004 0.143 0.020 (n=13 ) (n=15 (n=38 Part 1 (7.7) (26.7) 20 (52.6) 7 (53.8) 0.063 Working week Absent: Worked Lost (0.0) 6.5 (11.7) 28.7 0.12 (0.18) 2.9 (9.4) 1.7 (3.1) 30.5 (10.5) 0.17 (0.21) 3.0 (7.5) 3.8 (7.8) 22.0 (14.1) 0.34 (0.29) 3.1 (6.9) 13.7 (30.8) 28.8 (15.0) 0.60 (0.20) 0.216 0.472 0.109 <0.001 Total 0.1 (0.1) 0.2 (0.2) 0.3 (0.3) 0.6 Figure Box-plot visualizing impairment, assessed WPAI, score 0.00 indicates 1.00 corresponds impairment. Acknowledgements We want thank all BeSSTT participation. Disclosure Interests None Declared.